The Karimui Trial of BeG
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چکیده
A preliminary report of the "blind" controlled trial of BCG in progress at Karimui in the Eastem Highlands of the Territory of Papua and New Guinea has been published (In). In March 1963, 85 per cent of the 5,000 persons comprising the Karimui population were tested with 0.1 ml. of 1: 1,000 OT (10 TU ). In March 1964, a sample of 1,331 persons was retested and the results of these hlberculin survevs will be used to examine the following h·ypotheses. ( 1 ) No transmission of M. tuberculosis is occurring within the Ka.rimui population at the present time. (2) The tuberculin reactivity observed at Karimui is unlikely to be due to antigenic stimulation with anonymous mycobacteria. ( 3 ) Overt infection with M. leprae does not induce tubercu lin reactivity. (4) Presumed latent infection or n 'covelY from infection with M. l,,:prae does not induce tubercu lin reactivity. Karimui was selected for the trial of BCG vaccination as a prophylactic against leprosy in the belief that the area is virtually tubercu losis-free. The requir ments of the h'ial prohibit the use of lepromin ; hence it is not possible to study the relationship between the tuberculin and lepromin tests. Many surveys have indicatod that the tubercu lin index is very low iri the
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تاریخ انتشار 2012